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. 2024 Apr 12;15:1357932. doi: 10.3389/fphys.2024.1357932

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Copyright © 2024 Hebert, Funahashi, Emathinger, Nickerson, Groat, Andeen, Gurley and Hutchens.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Adult offspring of recovered RIAKI parents develop renal dysfunction with age. (A) The GFR of 12-week-old offspring was not significantly different, nor was (B) sex a factor. (C) By 6 months old, the GFR was reduced in all RIAKI offspring, (D) regardless of sex. (E) Between young (12 weeks) and middle (6 months) adulthood, males from RIAKI pairings gained significantly more weight than sham males, (F) with significantly steeper weight gain slopes (male slopes p = 0.005). T-test for two groups and one-way ANOVA with post hoc tests for multiple comparisons. *: p < 0.05. **: p < 0.01.