TABLE 1.
Molecular, biochemical, and serological characterization of the three HCV primary infections
| Patient | Causative event | Age (yr)/sex | HCV genotype | HCV viremiaa | ALT level (IU/ml)b | Results ofc:
|
|
|---|---|---|---|---|---|---|---|
| ELISA | RIBA3 | ||||||
| A | Transfusion (whole blood, 2 units) | 14/F | 1b | A1 (time zero): 1.1 × 107 | 800 | Neg | 0/1/0/0 |
| A2 (2 mo): 1.0 × 107 | 780 | Pos | 1/4/1/0 | ||||
| A3 (6 mo): 8.0 × 106 | 78 | Pos | 2/4/1/1 | ||||
| An′ (8 mo): <1 × 101 | 38 | Pos | 2/4/1/1 | ||||
| An" (9 mo): <1 × 101 | 25 | Pos | 2/4/2/2 | ||||
| A4 (12 mo): 2.5 × 104 | 97 | Pos | 3/4/3/2 | ||||
| B | Transmucosal infection (conjunctival blood splash) | 40/F | 1b | B1 (time zero): 5.0 × 105 | 165 | Neg | 0/1/0/0 |
| B2 (3 mo): 1.0 × 105 | 128 | Pos | 1/3/1/0 | ||||
| B3 (6 mo): 1.0 × 103 | 112 | Pos | 3/4/1/1 | ||||
| B4 (9 mo): 2.5 × 105 | 98 | Pos | 4/4/3/3 | ||||
| C | Surgical intervention (gastrectomy) | 32/M | 2c | C1 (time zero): 1.5 × 106 | 1185 | Neg | 0/0/0/0 |
| C2 (6 mo): 2.0 × 104 | 218 | Pos | 2/3/4/1 | ||||
| C3 (12 mo): 2.0 × 105 | 105 | Pos | 3/4/3/2 | ||||
a
Number of HCV RNA molecules per ml plasma. Time zero is the time where the first sample was available; other times are times after time zero. An′ and An" identify two consecutive samples that tested negative for HCV RNA.
b
Normal value, <40 IU/ml.
c
RIBA3 scores range negative (0) to strongly reactive (4) for c100/c33c/c22/NS5. For ELISA: neg, negative; pos, positive.