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. Author manuscript; available in PMC: 2025 Jan 1.
Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2023 Oct 28;1870(1):166928. doi: 10.1016/j.bbadis.2023.166928

Figure 2: Copper mildly decreases active zone protein BRP in a non-pathological model.

Figure 2:

(A) Non-pathological Htt-Q15 flies were driven by GMR-GAL4 and fed with different concentrations of CuCl2 until 10 DAE and 20 DAE. Lamina structures at 10 DAE and 20 DAE were stained for BRP (green) and cCas3 (gray). Scale bar = 30μm. (B) Quantification of tissue thickness of lamina neuropil (white bars shown on panel A). (C) Quantification of BRP intensity. (D) Quantification of cleaved caspase-3 intensity. Data are presented as mean ± SD. n=3-5, *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001.