Table 4. ARRDC3 and NFIA risk allele frequencies in 46 breed groups of US cattle.
| Risk allele frequency b | Animals in each group | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Disease risk d | Breeding rank e | ||||||||||
| Breed group a | Animals typed | ARRDC3 (BCHF5) | NFIA (BCHF2) c | 1× | 8× | 28× | 1 | 2 | 3 | 4 | 5 |
| Angus | 30 | 0.72 | 0.65 | 9 | 16 | 5 | 0 | 3 | 7 | 15 | 5 |
| Ankole-Watusi | 20 | 0.00 | 0.15 | 19 | 1 | 0 | 15 | 4 | 1 | 0 | 0 |
| Ayrshire | 24 | 0.02 | 0.50 | 17 | 7 | 0 | 7 | 9 | 8 | 0 | 0 |
| Beefmaster | 29 | 0.33 | 0.67 | 13 | 16 | 0 | 1 | 6 | 14 | 8 | 0 |
| Belgian Blue | 24 | 0.19 | 0.85 | 7 | 17 | 0 | 0 | 7 | 8 | 9 | 0 |
| Blonde d'Aquitaine | 24 | 0.06 | 0.42 | 19 | 5 | 0 | 9 | 8 | 6 | 1 | 0 |
| Brahman | 29 | 0.00 | 0.05 | 29 | 0 | 0 | 26 | 3 | 0 | 0 | 0 |
| Brahmousin | 24 | 0.00 | 0.29 | 22 | 2 | 0 | 12 | 10 | 2 | 0 | 0 |
| Brangus | 29 | 0.45 | 0.55 | 17 | 10 | 2 | 2 | 8 | 9 | 8 | 2 |
| Braunvieh | 28 | 0.00 | 0.50 | 21 | 7 | 0 | 7 | 14 | 7 | 0 | 0 |
| Brown Swiss | 24 | 0.00 | 0.50 | 18 | 6 | 0 | 6 | 12 | 6 | 0 | 0 |
| Charolais | 30 | 0.05 | 0.48 | 24 | 6 | 0 | 7 | 15 | 7 | 1 | 0 |
| Chianina | 28 | 0.18 | 0.54 | 17 | 10 | 1 | 5 | 10 | 10 | 2 | 1 |
| Corriente | 27 | 0.00 | 0.59 | 18 | 9 | 0 | 4 | 14 | 9 | 0 | 0 |
| Devon | 23 | 0.39 | 0.26 | 16 | 7 | 0 | 5 | 9 | 6 | 3 | 0 |
| Dexter | 24 | 0.00 | 0.31 | 23 | 1 | 0 | 10 | 13 | 1 | 0 | 0 |
| Gelbvieh | 29 | 0.03 | 0.48 | 20 | 9 | 0 | 9 | 11 | 8 | 1 | 0 |
| Guernsey | 24 | 0.00 | 0.56 | 19 | 5 | 0 | 2 | 17 | 5 | 0 | 0 |
| Hereford | 30 | 0.58 | 0.50 | 13 | 17 | 0 | 2 | 2 | 15 | 11 | 0 |
| Highland | 24 | 0.00 | 0.27 | 23 | 1 | 0 | 12 | 11 | 1 | 0 | 0 |
| Holstein | 23 | 0.09 | 0.63 | 16 | 7 | 0 | 1 | 12 | 9 | 1 | 0 |
| Indu-Brazil | 24 | 0.00 | 0.00 | 24 | 0 | 0 | 24 | 0 | 0 | 0 | 0 |
| Jersey | 38 | 0.00 | 0.58 | 24 | 14 | 0 | 8 | 16 | 14 | 0 | 0 |
| Limousin | 30 | 0.12 | 0.40 | 24 | 5 | 1 | 7 | 17 | 5 | 0 | 1 |
| Maine-Anjou | 29 | 0.24 | 0.76 | 13 | 15 | 1 | 0 | 7 | 16 | 5 | 1 |
| Marchgianna | 23 | 0.00 | 0.61 | 11 | 12 | 0 | 7 | 4 | 12 | 0 | 0 |
| Mini Hereford | 24 | 0.58 | 0.73 | 7 | 12 | 5 | 0 | 5 | 4 | 10 | 5 |
| Mini Zebu | 24 | 0.00 | 0.04 | 24 | 0 | 0 | 22 | 2 | 0 | 0 | 0 |
| Montbeliard | 24 | 0.08 | 0.42 | 21 | 3 | 0 | 7 | 11 | 5 | 1 | 0 |
| Murray Gray | 24 | 0.71 | 0.42 | 11 | 11 | 2 | 1 | 5 | 7 | 9 | 2 |
| Nelore | 24 | 0.00 | 0.31 | 23 | 1 | 0 | 10 | 13 | 1 | 0 | 0 |
| Piedmontese | 24 | 0.00 | 0.48 | 20 | 4 | 0 | 5 | 15 | 4 | 0 | 0 |
| Pinzgauer | 24 | 0.00 | 0.44 | 19 | 5 | 0 | 8 | 11 | 5 | 0 | 0 |
| Red Angus | 30 | 0.73 | 0.42 | 12 | 16 | 2 | 0 | 5 | 13 | 10 | 2 |
| Red Poll | 24 | 0.48 | 0.48 | 16 | 5 | 3 | 5 | 2 | 10 | 4 | 3 |
| Romagnola | 24 | 0.00 | 0.48 | 21 | 3 | 0 | 4 | 17 | 3 | 0 | 0 |
| Salers | 29 | 0.09 | 0.36 | 23 | 6 | 0 | 12 | 8 | 9 | 0 | 0 |
| Santa Gertrudis | 28 | 0.18 | 0.43 | 24 | 3 | 1 | 4 | 18 | 3 | 2 | 1 |
| Senepol | 24 | 0.02 | 0.65 | 15 | 9 | 0 | 2 | 12 | 10 | 0 | 0 |
| Shorthorn | 29 | 0.24 | 0.57 | 17 | 12 | 0 | 2 | 12 | 10 | 5 | 0 |
| Simmental | 30 | 0.13 | 0.42 | 23 | 6 | 1 | 9 | 13 | 5 | 2 | 1 |
| Tarentaise | 28 | 0.09 | 0.20 | 27 | 1 | 0 | 14 | 12 | 2 | 0 | 0 |
| T. Longhorn, MARC | 28 | 0.02 | 0.41 | 23 | 5 | 0 | 10 | 13 | 4 | 1 | 0 |
| T. Longhorn, CTLR | 23 | 0.04 | 0.61 | 14 | 9 | 0 | 3 | 10 | 10 | 0 | 0 |
| Tuli | 23 | 0.00 | 0.17 | 23 | 0 | 0 | 15 | 8 | 0 | 0 | 0 |
| Wagyu | 24 | 0.06 | 0.73 | 10 | 14 | 0 | 2 | 8 | 12 | 2 | 0 |
a
Registered cattle chosen for minimal pedigree relationships (Heaton et al., 2016).
b
The risk allele definitions are listed in Table 2.
c
Note that the LD is only moderate (r 2 ~ 0.47) between BCHF2 (BovineHD0300024366) and the SNPs most associated NFIA: BCHF31 (BovineHD0300024307), and BCHF32 (BovineHD0300024308). Thus, the BCHF2 allele values in this table are rough estimates of those for BCHF31 and BCHF32.
d
As described in Table 3.
e
As described in Table 3.