Table 2.

Summary table of studies of OGTT in PBH.

Study	Population	Type of OGTT when test was done	Definition of hypoglycaemia	Prevalence of hypoglycaemia
Roslin, 2011 (35)	RYGB, n=36 Symptoms not stated	75 g OGTT over 4 h At least 6 months post-op	≤60 mg/dL (3.3 mmol/L) or drop of ≥100 mg/dL (5.6 mmol/L) over 1 h	72% of RYGB
Chen, 2013 (36)	SG, n=33 RYGB, n=96 Pre-existing T2DM symptoms not stated	OGTT stimulus not stated, length not stated pre-op, 12 weeks and 12 months post-op	Not stated	36.4% of SG 12.5% of RYGB
Itariu, 2014 (37)	RYGB, n=30 SG, n=3 LAGB, n=3 Symptoms not stated	75 g OGTT over 2 h Pre-op and approximately 12 months post-op	<60 mg/dL (3.3 mmol/L)	50% overall, all in RYGB group 53% of RYGB None for SG and LAGB
Capristo, 2018 (29)	RYGB, n=59 (4 symptomatic) SG, n=60 (all asymptomatic)	75 g OGTT over 3 h At 12 months post-op	<55.8 mg/dL (3.1 mmol/L)	29% of RYGB 14% of SG
Pigeyre, 2015 (38)	RYGB, n=222, (including those symptomatic of dumping or hypoglycaemia) LAGB, n=129 (all asymptomatic)	75 g OGTT over 2 h At 12 months post-op	<50 mg/dL (2.8 mmol/L)	10% of RYGB None for LAGB
Brix, 2019 (39)	RYGB, n=175 SG, n=62 LAGB, n=44 All asymptomatic	75 g OGTT over 2 h At 24 months post-op	<2.8 mmol/L	32.6% after RYGB 22.6% after SG 2.3% after LAGB
Guarino, 2019 (40)	RYGB, n=35 Pre-existing T2DM (11 had mod-severe symptomatic hypoglycaemia)	75 g OGTT over 3 h Pre-op and at 24 months post-op	≤60 mg/dL (3.3 mmol/L)	31% of RYGB
Papamargaritis, 2019 (41)	SG, n=18 (symptoms not categorised though scoring included)	75 g OGTT over 2 h Pre-op and at 6 months post-op	<60 mg/dL (3.3 mmol/L)	44% of SG
Raverdy, 2016 (24)	RYGB, n=957 (prospective unselected cohort)	75 g OGTT over 2 h, pre- and 1 and 5 years post surgery	<50 mg/dL (2.8 mmol/L) and plasma insulin >3 mU/L at 120 min−	0.5% at baseline, 9.1% and 7.9% at 12 months and 60 months

LAGB, laparoscopic adjustable gastric banding; OGTT, oral glucose tolerance test; RYGB, Roux-en-Y gastric bypass; SG, sleeve gastrectomy; T2DM, type 2 diabetes mellitus.