Table 8.

Summary table of studies of glucagon or glucagon analogues in PBH.

Study	Population	Intervention	Comparator	Outcome
Halperin, 2010 (113)	Symptomatic RYGB, n = 1	Glucagon IV infusion in cross-over study	Vehicle	During MMT, glucagon eliminated the post-prandial hypoglycaemia evident with vehicle infusion.
Mulla, 2020 (112)	Symptomatic RYGB, n = 12	Automated glucagon SC boluses of 150 and 300 µg in cross-over study	Vehicle	During MMT, the algorithm predicted hypoglycaemia and administered glucagon boluses, obviating the need for rescue glucose treatment, and increasing nadir post-prandial plasma glucose in comparison to vehicle.
Nielsen, 2022 (114)	RYGB with hypoglycaemia on CGM, n = 10	Single dose of 80 µg or 200 µg dasiglucagon in three-way cross-over trial	Placebo	Increased nadir glucose and reduced time in hypoglycaemia <3.9 mmol/L during MMT compared to placebo, for both doses of dasiglucagon.

CGM, continuous glucose monitoring; IV, intravenous; MMT, mixed meal test; RYGB, Roux-en-Y gastric bypass; SC, subcutaneous.