Figure 3.

RAB5A knockdown in TNBC cells inhibits the release of miR-21. (A) The expression of macrophage polarization-associated miRNAs in exosomes from two TNBC cell lines. miRNA expression was normalized to that of siNC, *P < 0.05, siRAB5A vs siNC. Intracellular (B) and culture medium-released (C) miR-21 expression in two TNBC cell lines after RAB5A knockdown. (D) The intracellular expression of primary miR-21 (pri-miR-21) and precursor miR-21 (premiR-21) in two TNBC cell lines with RAB5A depletion. Intracellular mature miR-21 level in two TNBC cell lines with RAB5A knockdown after GW4869 administration. *P < 0.05, vs siNC.