Figure 7.

Macrophages induced malignance of TNBC cells. Cell viability (A), migration (B), invasion (C), and apoptosis (D) of two TNBC cell lines. PMA-pretreated THP-1 cells were first treated with or without exosomes from TNBC cells, and the conditioned medium from THP-1 cells was subsequently incubated with TNBC cells, *P < 0.05, vs Con. Cell viability (E), migration (F), invasion (G), and apoptosis (H) of two TNBC cell lines. PMA-pretreated THP-1 cells were first treated with exosomes derived from TNBC cells with or without RAB5A knockdown, and the conditioned medium from THP-1 cells was subsequently incubated with TNBC cells, *P < 0.05, vs siNC. Cell viability (I), migration (J), invasion (K), and apoptosis (L) of two TNBC cell lines. THP-1 cells were transfected with NC or miR-21 inhibitors. After PMA pretreatment, THP-1 cells were cocultured with TNBC cells in a Transwell coculture system, *P < 0.05, vs NC inhibitor.