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. Author manuscript; available in PMC: 2024 Apr 26.
Published in final edited form as: J Autoimmun. 2019 Jul 8;105:102300. doi: 10.1016/j.jaut.2019.06.011

Fig. 6.

Fig. 6.

Eos cKO Treg fail to suppress IBD. A) CD4+CD25−CD45RBhi T cells from 8-week-old mice C57BL/6 mice were injected (4 × 105 cells/mouse) into 8–10-week-old RAG−/− recipients. CD4+CD25+ cells (2 × 105 cells/mouse) from 3-month old Eosfl/fl or Eos cKO mice were co-injected where indicated. Mice were monitored weekly for weight loss. Data is plotted as percent weight change from original weight and is representative of two independent experiments (n = 5 per group). Mice were sacrificed on day 35 post transfer and mesenteric lymph node cells analyzed for: B) percentages of CD4+Foxp3− producing IFN-γ, IL-17, and IFN-γ/IL-17 double producers, and C) absolute number of CD4+Foxp3− T cells, and D) percentage of CD4+Foxp3+ T cells were shown.