. Author manuscript; available in PMC: 2024 Apr 26.

Published in final edited form as: J Autoimmun. 2019 Jul 8;105:102300. doi: 10.1016/j.jaut.2019.06.011

Table 1.

Comparison of different Eos deficient mouse strains.

Parameters	Eos^fl/fl X Foxp3^cre	Eos^fl/fl X CD4^cre	Eos global KO

Onset of Autoimmunity like symptoms	~3 months	~6–7 months	~12 months
CD4⁺Foxp3⁺	22.6	23.2	22
CD4⁺Foxp3⁺CD44^hi	80.4	80.6	86.2
CD4⁺Foxp3⁻CD44^hi	51	42.8	67.9
CD8⁺CD44^hi	12.3	15.6	45.7
Cellular infiltration in non-lymphoid organs	Kidneys, Salivary glands, liver and lungs	Salivary glands, Lungs and Kidneys	Salivary glands, kidneys, liver and lungs
CXCR5⁺PD-1⁺ (Tf cells)	11.8	9.5	NA
Tfr Cells	16.9	24.4	NA
CD4⁺Foxp3⁻IFN-γ⁺	31.9	28.3	NA
CD8⁺IFN-γ⁺	21	23.3	NA

The parameters are represented as average percentages in spleen tissue.