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. 1998 Dec;72(12):9567–9574. doi: 10.1128/jvi.72.12.9567-9574.1998

FIG. 3.

FIG. 3

Immunization with either rVV-ES-gB498-505 or rVV-gB498-505 protects mice from lethal challenge of HSV-2. Mice were immunized i.n. with either PBS-BSA (A to C), rVV-ES-gB498-505 (A to C), rVV-gB498-505 (C), or rVV-ES-IV (A and B) as described in Materials and Methods. Four to six weeks later, mice were administered i.n. a lethal challenge of 5 × 105 (A) or 105 (B and C) PFU HSV-2 186. Mice were monitored daily for lethality for 28 days. Panels A and B represent data from three and two independent experiments, respectively.