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Immunization with WSN/NA/gB confers protection from lethal HSV-2 infection. Mice were immunized i.n. with either PBS–1% FCS (n = 5) or WSN/NA/gB (n = 8) as described in Materials and Methods. Four weeks later, all mice were administered an i.n. challenge of 105 PFU HSV-2 186. Mice were monitored daily for lethality for 28 days.
