Table:
Demographic and clinical characteristics overall and by country
| Overall (n=1499) | Philippines (n=325) | Viet Nam (n=284) | South Africa (n=300) | Uganda (n=314) | India (n=276) | |
|---|---|---|---|---|---|---|
|
| ||||||
| Sex | ||||||
| Female | 686 (45·8%) | 180 (55·4%) | 110 (38·7%) | 148 (49·3%) | 135 (43·0%) | 113 (40·9%) |
| Male | 813 (54·2%) | 145 (44·6%) | 174 (61·3%) | 152 (50·7%) | 179 (57·0%) | 163 (59·1%) |
| Mean age, years | 41·0 (29·0–54·0) | 39·0 (25·0–52·0) | 53·0 (40·0–64·0) | 38·5 (31·0–48·0) | 32·0 (25·0–42·0) | 47·0 (35·0–59·5) |
| Median BMI, kg/m2 | 21·4 (19·1–25·2) | 23·8 (20·2–27·5) | 20·2 (18·7–21·8) | 22·2 (19·3–28·4) | 20·9 (19·0–24·0) | 22·4 (18·9–25·9) |
| Cough for 2 weeks | 1499 (100%) | 325 (100%) | 284 (100%) | 300 (100%) | 314 (100%) | 276 (100%) |
| Fever | 533 (35·6%) | 50 (15·4%) | 101 (35·6%) | 107 (35·7%) | 210 (66·9%) | 65 (23·6%) |
| Weight loss | 702 (46·8%) | 91 (28·0%) | 84 (29·6%) | 192 (64·0%) | 213 (67·8%) | 122 (44·2%) |
| Night sweats | 528 (35·2%) | 56 (17·2%) | 92 (32·4%) | 162 (54·0%) | 192 (61·1%) | 26 (9·4%) |
| Previous tuberculosis diagnosis* | 290 (19·3%) | 43 (13·2%) | 59 (20·8%) | 111 (37·0%) | 38 (12·1%) | 39 (14·1%) |
| Person living with HIV† | ||||||
| Yes | 229 (15·3%) | 3 (0·9%) | 2 (0·7%) | 118 (39·7%) | 96 (30·6%) | 10 (3·6%) |
| Median CD4 count, cells per μL | 399 (206–667) | 527·0 (184–812) | 547 (497–597) | 402 (206–667) | 377 (211–636) | 587 (220–692) |
| Diabetes | 202 (13·5%) | 42 (12·9%) | 67 (23·6%) | 18 (6·0%) | 25 (8·0%) | 50 (18·1%) |
| Sputum Xpert Ultra status‡ positive | 297 (19·8%) | 22 (6·8%) | 96 (33·8%) | 49 (16·3%) | 106 (33·8%) | 24 (8·7%) |
| Highest semiquantitative sputum Xpert Ultra result | ||||||
| Trace§ | 9 (3·0%) | 1 (4·5%) | 0 | 3 (5·8%) | 4 (3·7%) | 1 (4·0%) |
| Very low | 44 (14·5%) | 5 (22·7%) | 14 (14·6%) | 10 (19·2%) | 11 (10·2%) | 4 (16·0%) |
| Low | 95 (31·4%) | 8 (36·4%) | 38 (39·6%) | 13 (25·0%) | 26 (24·1%) | 10 (40·0%) |
| Medium | 76 (25·1%) | 6 (27·3%) | 22 (22·9%) | 12 (23·1%) | 29 (26·9%) | 7 (28·0%) |
| High | 79 (26·1%) | 2 (9·1%) | 22 (22·9%) | 14 (26·9%) | 38 (35·2%) | 3 (12·0%) |
| Tuberculosis microbiological reference standard positive | 329 (21·9%) | 29 (8·9%) | 108 (38·0%) | 57 (19·0%) | 109 (34·7%) | 26 (9·4%) |
| Venous or capillary blood collection | ||||||
| Capillary | 286 (19·1%) | 0 | 0 | 286 (95·3%) | 0 | 0 |
| Venous | 1213 (80·9%) | 325 (100%) | 284 (100%) | 14 (4·7%) | 314 (100%) | 276 (100%) |
Data are n (%) or median (IQR).
Three participants were unsure about previous tuberculosis diagnoses and treated as missing data for this variable. All participants with previous tuberculosis diagnoses had not taken tuberculosis treatment within the past 12 months.
Three participants had an unknown HIV status.
One participant was missing a sputum Xpert Ultra result, six of nine participants had only a single Xpert Ultra trace result and were therefore considered Xpert Ultra negative.
Five of nine participants were positive by microbiological reference standard including three participants with two trace results; four of nine participants had a single trace result with negative second Xpert Ultra and negative tuberculosis culture.