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Rapid induction of protection by the live-attenuated NoVΔB2 in adult Rag1−/− mice. (A and B) Survival and body weight change of the adult Rag1−/− mice that were immunized with buffer, live or killed NoVΔB2 and 2 (A) or 14 (B) d later, challenged with a lethal dose of NoV. Survival curves were compared using a log rank (Mantel-Cox) test whereas body weight changes between immunization by live and killed NoVΔB2 were analyzed by Multiple unpaired t tests.
