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Osimertinib AUC as a function of hepatic dysfunction as defined by NCI-ODWG or Child-Pugh criteria. Circles represent individual AUCss values based on population PK analysis using the NCI-ODWG criteria in the population PK set. For the phase 1 PK hepatic impairment study, individual AUC values are shown. AUCss, area under the plasma concentration time curve at steady state; NCI-ODWG, National Cancer Institute Organ Dysfunction Working Group; PK, pharmacokinetics.
