Table 2.
Association of insulin resistance index with new onset hypertension
| Incidence of total hypertension | ||||||||
|---|---|---|---|---|---|---|---|---|
| Crude model | Model 1 | Model 2 | ||||||
| HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | |||
| TyG index | 1.804 (1.620–2.008) | < 0.001 | 1.135 (0.999–1.290) | 0.052 | 1.083 (0.951–1.235) | 0.22 | ||
| TG/HDL-C | 1.097 (1.076–1.118) | < 0.001 | 1.029 (1.002–1.056) | 0.03 | 1.023 (0.995–1.052) | 0.10 | ||
| METS-IR | 5.135 (3.893–6.774) | < 0.001 | 1.594 (1.111–2.286) | 0.01 | 1.389 (0.958–2.014) | 0.08 | ||
| ZJU index | 1.012 (1.010–1.015) | < 0.001 | 1.003 (0.999–1.007) | 0.10 | 1.003 (0.999–1.008) | 0.09 | ||
| Incidence of stage I hypertension | ||||||||
| TyG index | 1.716 (1.566–1.981) | < 0.001 | 1.102 (0.958–1.268) | 0.17 | 1.049 (0.909–1.210) | 0.51 | ||
| TG/HDL-C | 1.115 (1.088–1.141) | < 0.001 | 1.037 (1.004–1.071) | 0.02 | 1.028 (0.995–1.063) | 0.10 | ||
| METS-IR | 5.146 (3.783–6.999) | < 0.001 | 1.611 (1.085–2.392) | 0.01 | 1.392 (0.927–2.090) | 0.11 | ||
| ZJU index | 1.012 (1.009–1.014) | < 0.001 | 1.002 (0.997–1.007) | 0.50 | 1.001 (0.996–1.006) | 0.59 | ||
| Incidence of stage II hypertension | ||||||||
| TyG index | 2.907 (2.254–3.749) | < 0.001 | 1.527 (1.111–2.101) | 0.009 | 1.409 (1.024–1.939) | 0.03 | ||
| TG/HDL-C | 1.141 (1.101–1.183) | < 0.001 | 1.057 (1.002–1.115) | 0.04 | 1.044 (0.987–1.105) | 0.13 | ||
| METS-IR | 15 733 (8.195–30.205) | < 0.001 | 2.998 (1.203–7.473) | 0.01 | 2.317 (0.904–5.938) | 0.08 | ||
| ZJU index | 1.018 (1.014–1.023) | < 0.001 | 1.010 (1.004–1.017) | 0.002 | 1.010 (1.004–1.017) | 0.002 | ||
Data are presented as hazard ratios (HR) and 95% confidence intervals (CI) using multivariable Cox regression analysis
Model 1: adjust for age, sex, alcohol intake, tobacco smoking, family history for early-onset cardiovascular diseases or hypertension, physical activity levels, systolic blood pressure, diastolic blood pressure, and body mass index
Model 2: adjusted for variables in the Model 1 + low-density lipoprotein cholesterol, serum uric acid, blood urea nitrogen and estimated glomerular filtration rate
Abbreviations: AUC: area under curve; TyG, triglyceride glucose; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; METS-IR, metabolic score for insulin resistance; ZJU, Zhejiang University