Table 1.

Statistical comparison of the calculated sum and the measured effects of pairs of RORγ agonists of data shown in Fig. 5A.

Agonist [2.5 μM]	% increase in RORγ activity (mean ± SD)	Calculated sum of % increase in RORγ activity (mean ± SD)	Measured % increase in RORγ activity of the mixture (mean ± SD)
Benzylparaben	45 ± 2	108 ± 15	96 ± 5 (ns)
Benzophenone-10	63 ± 4
Benzylparaben	45 ± 2	128 ± 8	102 ± 13 (*)
Hexylparaben	83 ± 8
Benzophenone-10	83 ± 8	146 ± 11	132 ± 4 (ns)
Hexylparaben	63 ± 4

RORγ activity was normalized to the vehicle control. The sums of RORγ activity of combinations of two agonistic compounds was calculated for each experimental replicate. Statistical analysis was performed by one-way ANOVA followed by the pairwise t-test with Bonferroni-adjusted p values. The calculated sums of RORγ activity of the two agonists were compared to the measured RORγ activity of their respective mixtures. P values:

^*< 0.05

ns (not significant). Data represent mean ± SD from three independent experiments.