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. Author manuscript; available in PMC: 2024 Apr 26.
Published in final edited form as: Toxicology. 2022 Mar 23;471:153159. doi: 10.1016/j.tox.2022.153159

Table 2.

Statistical comparison of the calculated sum and the measured effects of nine RORγ agonists of data shown in Fig. 5B.

Agonist [1 μM] % increase in RORγ activity (mean ± SD)
Butylparaben 5 ± 4
Heptylparaben 5 ± 5
Phenylparaben 5 ± 2
Benzylparaben 13 ± 4
Benzophenone-10 15 ± 5
Benzophenone-6 −1 ± 5
Benzylbenzoate 16 ± 12
Benzylsalicylate 18 ± 3
4-Methylphenylbenzoate 6 ± 9
Calculated sum of % increase in RORγ activity (mean ± SD) 81 ± 2
Measured % increase in RORγ activity of the mixture (mean ± SD) 90 ± 11 (ns)

RORγ activity was normalized to the vehicle control. The sum of RORγ activity of all nine agonistic compounds was calculated for each experimental replicate. The calculated sum of RORγ activity of the nine agonists was compared to the measured RORγ activity of the respective mixture in a t-test. The two groups were not significantly different (ns). Data represent mean ± SD from three independent experiments.