Table 1.
Median (95% CI) pharmacokinetic parameters after enteral dosing of CBD/CBDA-rich hemp oil in horses using a non-compartmental model.
| Analyte | Cmax | Tmax | T0.5Elim | AUC | MRT |
|---|---|---|---|---|---|
| CBD (2 mg/kg) | 5.2 (2.93–8.95) | 3.0 (1.52–5.48) | NA | 44 (26.52–66.34) | NA |
| CBD (8 mg/kg) | 40.35 (27.70–52.17) | 8.0 (4.16–10.34) | 8.3 * (6.37–8.93) | 501.5 (343.25–687.50) | 12.6 (10.29–14.16) |
| THC (8 mg/kg) | 6.65 (5.52–8.25) | 6.0 (3.54–9.96) | NA | 98.0 (70.74–121.51) | NA |
| THCA (2 mg/kg) | 7.65 (5.32–14.47) | 1.25 (0.97–2.63) | 10.6 ** (8.58–18.21) | 127.0 (100.73–185.3) | 12.45 (11.42–13.78) |
| 7-COOH-CBD (2 mg/kg) | 133.75 (89.71–169.89) | 12.0 (7.87–19.14) | NA | 4,450.5 (3206.9–6520.6) | 71.4 (57.34–100.44) |
| 7-COOH-CBD (8 mg/kg) | 777.5 (630.1–857.4) | 12.0 (7.87–19.14) | NA | 27,874 (22,851-32,108) | 97.1 (73.73–136.82) |
Maximum plasma concentration (ng/mL), Cmax; time at maximum plasma concentration (hours), Tmax; elimination half-life (hours), T0.5Elim; area under the curve (h*ng/mL), AUC; mean residence time (hours), MRT. *T 0.5 elim is based on 6/8 horses with three points beyond Cmax; ** T 0.5 elim is based on 7/8 horses with three points beyond Cmax. NA – not applicable due to being a metabolite or horse number for proper analysis being less than 6 horses in the cohort.