Table 2.
Median (95% CI) pharmacokinetic parameters of CBDA and THCA after enteral dosing of CBD/CBDA-rich hemp oil in horses using a non-compartmental model.
| Analyte | CmaxP1 | TmaxP1 | CmaxP2 | TmaxP2 | AUC | MRT |
|---|---|---|---|---|---|---|
| CBDA (2 mg/kg) | 20.05 (4.14–69.76) | 0.5 (0.24–1.13) | 17.7 (10.12–28.97) | 8.0 (4.53–10.05) | 410.5 (289.53–560.97) | 12.8 (11.49–14.14) |
| CBDA (8 mg/kg) | 312.2 (92.67–614.45) | 0.5 (0.43–1.07) | 164.45 (115.88–251.54) | 4.0 (3.54–7.21) | 3,353 (2,753.3–4,006.7) | 13.1 (11.03–15.77) |
| THCA (8 mg/kg)* | 76.3 (16.03–121.75) | 1.3 (0.97–4.43) | 59.3 (38–43-89.97) | 4.0 (3.83–7.57) | 1,130 (789.2–1,336.72) | 14.4 (13.05–15.55) |
Maximum plasma concentration of peak 1 (ng/mL), CmaxP1; time of maximum plasma concentration of peak 1 (hours), TmaxP1; maximum plasma concentration of peak 2 (ng/mL), CmaxP2; time of maximum plasma concentration of peak 2 (hours), TmaxP2; area under the curve (h*ng/mL), AUC; mean residence time (hours), MRT. *THCA CmaxP2 and TmaxP2 are data from 5 horses as 3 did not show a “double peak.”