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. 2020 Jan;372(1):107–118. doi: 10.1124/jpet.119.261800

Fig. 4.

Fig. 4.

(A) Three-point concentration response of ABBV-2222 and tezacaftor on F508delCFTR maturation in the CFBE cells as reflected by band C. Compounds were incubated for 24 hours with the cells prior to harvesting and lysis. (B) Bar graph showing mean with S.D. from n = 3 replicates of the band C/B ratio including the representative western blot experiment shown in (A). (C) Concentration response of ABBV-2222 and tezacaftor on F508delCFTR function in the CFBE-DG3 cells measured in the TECC assay in the presence of the potentiator GLPG1837. The EC50 value for ABBV-2222 was 20.8 ± 2.7 nM compared with 266.9 ± 38.6 nM for tezacaftor (n = 6 replicates at each concentration tested).