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PXL770 improves VLCFA levels in Abcd1 KO mice. VLCFA content measured by LC-MS in (A) plasma and (B) brain from 6- to 8-week-old Abcd1 KO mice treated with PXL770 at 75 mg/kg (BID – Oral) for 8 weeks. Data are mean ± SEM, n = 12 animals for wild-type and n = 15 for KO untreated and PXL770. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 (Dunnett’s test versus untreated).
