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. 2024 Apr 15;121(17):e2319476121. doi: 10.1073/pnas.2319476121

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Copyright © 2024 the Author(s). Published by PNAS.

This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 3. — CG-MD simulations identify protein insertase complexes as lipid scramblases. (A) All members of the Oxa1 family of insertases have in silico lipid scrambling activity in their monomeric form. Left: 3D structure of selected members of the Oxa1 family. Right: In silico lipid scrambling quantification. The negative control EcGlpG is shown as reference. (B) Mitochondrial insertase complexes have in silico lipid scrambling activity. Left: 3D structure of selected mitochondrial insertase complexes. Right: In silico lipid scrambling quantification. (C) ER insertase complexes have in silico lipid scrambling activity. Left: 3D structure of selected ER insertase complexes. Right: In silico lipid scrambling quantification. AlphaFold structures are denoted by the * symbol, number of proteins in the complex is in parenthesis.