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. 2015 Jun;353(3):490–495. doi: 10.1124/jpet.115.223420

Fig. 3.

Fig. 3.

Effect of cyclophilin inhibition on markers of plaque stability and oxidation. (A) Quantitation of collagen content in of the aortic sinus after staining with Masson’s trichrome. Percentages of positive staining of total lesion area are shown. (B) Representative micrographs of staining of the aortic sinus with Masson's trichrome of mice treated with vehicle (left), NIM811 (center), and MM284 (right). (C) Quantitation of collagen content in the innominate artery. Percentages of positive staining of total lesion area are shown. (D) Representative micrographs of staining of the innominate artery with Masson's trichrome of mice treated with vehicle (left), NIM811 (center), and MM284 (right). (E) Quantitation of nitrotyrosine content in of the aortic sinus. Percentages of positive anti nitrotyrosine staining of total lesion area are shown. (F) Representative micrographs of staining of the aortic sinus for nitrotyrosine in mice treated with vehicle (left), NIM811 (center), and MM284 (right). (G) Quantitation of nitrotyrosine contents in the innominate artery. Percentages of positive anti nitrotyrosine staining of total lesion area are shown. (H) Representative micrographs of staining of the innominate artery for nitrotyrosine in mice treated with vehicle (left), NIM811 (center), and MM284 (right). All graphs are presented as mean ± S.E.M., *P < 0.05 versus vehicle; **P < 0.001 versus vehicle.