Fig. 6.

The effect of cannabinoid and βAR ligands on IOP in CB₁(−/−) and CB₂(−/−) mice on a C57BL6 genetic background. A, mean IOP data recoded from either C57BL6 CB₁(−/−) (n = 3) mice or CB₁(+/+) (n = 5) littermates after the topical application of either vehicle or WIN (1%). **, p < 0.01; *, p < 0.05 compared with the appropriate vehicle control. B, mean IOP measured in CB₁(−/−) mice after treatment with vehicle and timolol (0.5%; n = 4), ISO (1%; n = 3), or latanoprost (0.005%; n = 4). C, IOP measured in CB₂(−/−) mice after 1-h topical administration of WIN (1.0%; solid bars) or timolol (0.5%; open bars). ***, p < 0.001; **, p < 0.01 compared with the appropriate vehicle control.