Fig. 5.

A, effect of CB2 receptor activation and APJ blockade on protein expression of PDGFRβ and TIMP1. Representative Western blot for PDGFRβ and TIMP1 in liver tissue of control rats (CT), fibrotic rats receiving vehicle (CCl₄), and fibrotic rats treated with either AM1241 (CCl₄ + AM1241, 1 mg/kg per day b.wt.) or F13A (CCl₄ + F13A, 75 μg/kg per day b.wt.) for 5 weeks. Eighty micrograms of protein was loaded per lane. B, bars at the bottom show the densitometric analysis of all the samples normalized to GAPDH. Results are given as means ± S.E. a, p < 0.05; b, p < 0.01; c, p < 0.001 versus control; *, p < 0.05; **, p < 0.01; ***, p < 0.001 versus CCl₄.