TABLE 3.
MMP/TIMP ratios calculated from the mRNA expression of MMP2, MMP9, TIMP1, and TIMP2 in liver tissue of fibrotic rats receiving vehicle or treated with the CB2 agonist AM1241 or the APJ antagonist F13A
Results are given as means ± S.E.
| Gene Ratio | CCl4-Treated Rats |
|||
|---|---|---|---|---|
| CB2 Stimulation |
APJ Blockade |
|||
| Vehicle | AM1241 | Vehicle | F13A | |
| MMP2/TIMP1 | 0.91 ± 0.24 | 0.88 ± 0.21 | 1.43 ± 0.27 | 1.56 ± 0.12 |
| MMP2/TIMP2 | 2.66 ± 0.48 | 2.18 ± 0.27 | 2.80 ± 0.26 | 2.09 ± 0.13 |
| MMP9/TIMP1 | 1.79 ± 0.40 | 4.56 ± 0.96* | 2.13 ± 0.54 | 4.91 ± 1.0* |
| MMP9/TIMP2 | 6.75 ± 1.36 | 15.7 ± 3.47* | 4.39 ± 1.04 | 9.14 ± 3.35 |
*
p < 0.05; unpaired Student's t test.