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. 2024 Apr 6;84:101933. doi: 10.1016/j.molmet.2024.101933

Figure 2.

Figure 2

Mesenchymal stem cell-specific Alms1 knockout recapitulate the insulin resistance of global Alms1 loss. (A–D) Daytime non-fasted blood glucose and insulin concentrations at 10 and 19 weeks of age. (E,G) Insulin tolerance tests (ITT) and (F,H) oral glucose tolerance tests (oGTT). Global WT/KO and MSC WT/KO experiments were performed with identical design at different times, reflected in the dotted line separating comparisons in (A–D, I–N). oGTT and ITT graphs (E–H) show mean ± sd for each time point. All other graphs (A–D, I–N) plot data points representing individual animals, with bars representing mean ± sd. Comparisons of log10 oGTT insulin values (B,D,M,N) and glucose concentration (A,C) were performed by two-way ANOVA with Šídák's multiple comparisons test. Comparison of all other data (I–L) used an unpaired two-tailed Student's t-test with Bonferroni correction. ∗ denotes p < 0.05, ∗∗ denotes p < 0.01, ∗∗∗ denotes p < 0.001 and ∗∗∗∗ denotes p < 0.0001. For females N = 7, 8, 8 and 8 for global WT, global KO, MSC WT and MSC KO respectively. For males N = 8, 8, 7 and 7 for global WT, global KO, MSC WT and MSC KO respectively. AOC = area of the curve; ns = not significant.