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Administration of GS-6201, given immediately after coronary ligation (4 mg/kg i.p. twice daily), prevented caspase-1 activation in the heart tissue measured 72 h after surgery and significantly inhibited leukocyte (CD45+) recruitment in the heart. *, P < 0.001 versus sham; #, P < 0.01 versus vehicle (n = 4–6 per group).
