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Schematic representation of the multifaceted mechanism-of-action of namodenoson. The scheme demonstrates the effect of namodenoson on diseased liver, hematopoietic cells, and adipocytes through its binding to A3AR. This binding leads to deregulation of PI3K, which ultimately results in inhibition of HCC growth, inhibition of MASLD/MASH-associated inflammation, as well as to liver protection. Grey lines represent inhibitory effects; green arrows represent activation effects.
