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Egr1 directly binds to the MMP-12 promoter. (A) Hct116 cells transduced with LVShEgr1 and LVshLuc were transfected with pFRL2-h.MMP12 promoter. Total cell lysates were collected 48 h post-transfection and luciferase activities were determined using a chemiluminescence analyzer. (B) Chromatin immunoprecipitation (ChIP) assay was performed in Hct166 cells using the anti-Egr1 antibody, with normal IgG serving as the negative control.
