Figure 1.

The primary sterol synthesis pathways discussed in this review, demonstrating potential chemical inhibitors for each of the key enzyme steps. * This list is not exhaustive but is meant to demonstrate the breadth of compounds potentially inhibiting each step, including both specific inhibitors and FDA-approved medications (the latter denoted by italics). CYP51A1, cytochrome P450 family 51 subfamily A member 1; LBR, lamin B receptor; SC5D, sterol-C5-desaturase; 7-DHC, 7-dehydrocholesterol; TASIN, truncated adenomatous polyposis coli selective inhibitors.