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. 2024 Apr 3;11(4):352. doi: 10.3390/bioengineering11040352

Table 2.

Least squared means and standard errors for each sleep stage, stratified by sex and cool vs. warm temperatures for Pod OFF as a reference compared to Pod ON.

Variable Men Women Effect Modification by Sex: Cool Effect Modification by Sex: Warm
OFF (Ref) Cool Warm OFF (Ref) Cool Warm
lsmean ± SE p-Value lsmean ± SE p-Value lsmean ± SE lsmean ± SE p-Value lsmean ± SE p-Value p-Value p-Value
Bedtime
SOL 28.5 ± 4.1 28.7 ± 5.1 0.965 26.0 ± 4.6 0.452 31.5 ± 3.9 33.0 ± 5.3 0.756 24.2 ± 4.5 0.079 0.756 0.079
Deep SOL 16.8 ± 2.2 10.0 ± 3.2 0.045 11.5 ± 2.7 0.066 18.4 ± 4.3 8.5 ± 6.2 0.124 23.1 ± 5.0 0.377 0.654 0.100
Early Phase
Deep (min) 64.3 ± 4.9 78.6 ± 5.7 0.003 70.9 ± 6.3 0.205 68.5 ± 6.5 63.6 ± 7.1 0.305 61.8 ± 7.3 0.194 0.005 0.071
Deep (%) 17.3 ± 1.5 20.1 ± 1.7 0.051 18.7 ± 1.9 0.389 17.4 ± 1.7 16.8 ± 1.9 0.669 15.9 ± 1.9 0.292 0.089 0.178
REM (min) 37.2 ± 3.34 30.5 ± 4.0 0.072 35.3 ± 4.5 0.628 35.0 ± 4.2 44.3 ± 4.9 0.033 35.5 ± 5.1 0.924 0.005 0.702
REM (%) 10.0 ± 0.9 7.8 ± 1.1 0.061 9.1 ± 1.3 0.476 9.3 ± 1.1 11.7 ± 1.3 0.028 8.8 ± 1.4 0.686 0.004 0.823
Light (min) 113.0 ± 5.9 105.0 ± 6.6 0.075 108.0 ± 7.0 0.341 115.0 ± 6.7 108.0 ± 7.4 0.169 109.0 ± 7.6 0.301 0.843 0.923
Light (%) 30.5 ± 1.9 27.0 ± 2.2 0.047 28.4 ± 2.4 0.291 29.8 ± 1.9 28.4 ± 2.1 0.326 28.8 ± 2.2 0.527 0.401 0.664
Wake (min) 22.8 ± 2.2 22.0 ± 2.8 0.754 21.7 ± 3.1 0.713 20.6 ± 3.1 23.5 ± 3.6 0.375 24.7 ± 3.8 0.236 0.412 0.236
REM SOL 111.0 ± 45.9 116.6 ± 51.2 0.694 132.6 ± 81.1 0.443 122.4 ± 64.5 101.8 ± 75.2 0.181 144.6 ± 52.4 0.202 0.200 0.634
Late Phase
Deep (min) 7.3 ± 1.4 7.3 ± 1.6 0.993 4.6 ± 2.0 0.181 9.2 ± 2.1 10.4 ± 2.7 0.654 7.1 ± 2.7 0.460 0.700 0.902
Deep (%) 1.8 ± 0.3 1.8 ± 0.4 0.957 1.1 ± 0.5 0.188 2.3 ± 0.5 2.6 ± 0.6 0.622 1.8 ± 0.6 0.499 0.692 0.771
REM (min) 55.6 ± 5.6 48.7 ± 6.5 0.257 66.5 ± 7.9 0.142 45.6 ± 4.3 48.0 ± 5.5 0.678 47.8 ± 5.5 0.706 0.219 0.328
REM (%) 13.4 ± 1.2 11.6 ± 1.4 0.159 15.2 ± 1.7 0.252 11.4 ± 0.9 11.8 ± 1.2 0.792 11.4 ± 1.2 0.990 0.221 0.346
Light (min) 94.4 ± 6.9 105.0 ± 8.2 0.204 117.8 ± 10.2 0.023 105.0 ± 7.1 106.0 ± 8.7 0.967 113.0 ± 8.9 0.405 0.378 0.242
Light (%) 23.1 ± 1.3 25.5 ± 1.6 0.166 28.2 ± 2.0 0.016 26.1 ± 1.4 26.1 ± 1.7 0.983 27.5 ± 1.8 0.403 0.300 0.190
Wake (min) 21.0 ± 2.4 18.3 ± 2.8 0.216 24.2 ± 3.4 0.046 18.7 ± 3.2 24.0 ± 4.0 0.186 26.9 ± 4.0 0.044 0.082 0.377

Note: OFF indicates all nights of Pod OFF as a reference for comparing with Pod ON at cool or warm temperatures for Bedtime, Early, and Late Phases for women and men. See Section 2 for the description of cool vs. warm bins. Bolded values indicate significance at p < 0.05. lsmeans: least squared means; SE: standard error; SOL: sleep onset latency; Early Phase: first four hours of sleep after sleep onset; Late Phase: end of Early Phase until waking; Cool: those who slept at cool Pod temperatures during Early or Late Phase (see Section 2 for details); warm: those who slept at warm Pod temperatures during Early or Late Phases (see Section 2 for details).