Table 2.
Drug | Mutation | ||
---|---|---|---|
Major | Accessory | ||
First-generation INSTI | Raltegravir [156] | R263K, N155H, Q148HKR, Y143RHC, F121Y | L74M, E138AK, G140AS, E92Q, T97A |
Elvitegravir [157,158] | R263K, N155H, Q148HKR, S147G, F121Y, E92Q, T66I | T97A, E92G, T66AK | |
Second-generation INSTI | Dolutegravir [159] | R263K, Q148HKR, G118R | N155H, G140AS, E138AKT, T66K, E92Q, F121Y |
Bictegravir [160] | R263K, Q148H | G140S, E138K, T66K, E92Q, G118R | |
Cabotegravir [160] | R263K, Q148HKR, G140R, G118R | N155H, S153FY, G140ACS, E138AKT, T66K |