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. 2024 Apr 20;12(4):915. doi: 10.3390/biomedicines12040915

Table 2.

INSTIs resistance mutations (Adapted from [155]).

Drug Mutation
Major Accessory
First-generation INSTI Raltegravir [156] R263K, N155H, Q148HKR, Y143RHC, F121Y L74M, E138AK, G140AS, E92Q, T97A
Elvitegravir [157,158] R263K, N155H, Q148HKR, S147G, F121Y, E92Q, T66I T97A, E92G, T66AK
Second-generation INSTI Dolutegravir [159] R263K, Q148HKR, G118R N155H, G140AS, E138AKT, T66K, E92Q, F121Y
Bictegravir [160] R263K, Q148H G140S, E138K, T66K, E92Q, G118R
Cabotegravir [160] R263K, Q148HKR, G140R, G118R N155H, S153FY, G140ACS, E138AKT, T66K