Table 3.

List of Some of the Registered Clinical Trials Using Exosomes Therapy for Managing Neurodegenerative Diseases, Cardiovascular Disorders, Cancers and Diabetes

NCT Number		Study Status	Conditions	Interventions	Sponsor
Neurodegenerative diseases	NCT05888558	Enrolling by invitation	Myasthenia Gravis	Device: body fluid diagnosis	First Affiliated Hospital of Jinan University
	NCT03275363	Unknown	Mild Cognitive Impairment Alzheimer Dementia Vascular Dementia Age-related Cognitive Decline	Diagnostic test: neurocognitive battery, diagnostic test: MRI, biological: blood tests, diagnostic test: EEG with event-related potential (ERP), diagnostic test: amyloid pet CT	The University of Hong Kong
	NCT05163626	Not yet recruiting	Alzheimer Disease	Behavioral: combined aerobic exercise and cognitive training program	Xuanwu Hospital, Beijing
	NCT04202770	Suspended	Refractory Depression, Anxiety Disorders, Neurodegenerative Diseases	Other: exosomes	Neurological Associates of West Los Angeles
	NCT04388982	Unknown	Alzheimer Disease	Biological: low dosage MSCS-EXOS administrated for nasal drip, biological: mild dosage MSCS-EXOS administrated for nasal drip, biological: high dosage MSCS-EXOS administrated for nasal drip	Ruijin Hospital
	NCT01860118	Completed	Parkinson’s disease		University of Alabama at Birmingham
	NCT01811381	Unknown	Mild Cognitive Impairment	Drug: curcumin, behavioral: aerobic yoga, behavioral: non aerobic yoga, dietary supplement: placebo	VA Office of Research and Development
Cardiovascular diseases	NCT Number	Study status	Conditions	Interventions	Sponsor
	NCT05326724	Recruiting	Exosome, Post-stroke Dementia, Acupuncture	Device: acupuncture	China Medical University Hospital
	NCT05035134	Unknown	Intracerebral hemorrhage circulating exosomes		Tang-Du Hospital
	NCT03275363	Unknown	Neurocognitive Disorder, Mild Cognitive Impairment, Alzheimer Dementia, Vascular Dementia, Age-related Cognitive Decline	Diagnostic test: neurocognitive battery, diagnostic test: MRI, biological: blood tests, diagnostic test: EEG with event-related potential (ERP), diagnostic test: amyloid pet CT	The University of Hong Kong
	NCT06070974	Recruiting	STEMI	Diagnostic test: CMR and blood collection	Centro Cardiologico Monzino
	NCT03034265	Completed	Hypertension		Insel Gruppe AG, University Hospital Bern
	NCT06138210	Not yet recruiting	Acute Ischemic Stroke	Drug: exosomes derived from human induced pluripotent stem cell for injection, drug: a placebo of exosomes derived from human induced pluripotent stem cell for injection	Xuanwu Hospital, Beijing
	NCT03478410	Unknown	Atrial Fibrillation	Procedure: epicardial fat biopsy	Sheba Medical Center
	NCT05490173	Not yet recruiting	Premature Birth, Extreme Prematurity, Preterm Intraventricular Hemorrhage, Hypoxia-Ischemia, Cerebral, Neurodevelopmental Disorders	Other: exosomes derived from mesenchymal stromal cells (MSCS)	Federal State Budget Institution Research Center for Obstetrics, Gynecology and Perinatology Ministry of Healthcare
Cancers	NCT04258735	Recruiting	Metastatic Breast Cancer	Diagnostic test: genomic analysis	Samsung Medical Center
	NCT04357717	Terminated	Prostate Cancer	Diagnostic test: EXODX prostate	Exosome Diagnostics, Inc.
	NCT03830619	Completed	Lung Cancer (Diagnosis)	Diagnostic test: collect samples	Wuhan Union Hospital, China
	NCT06193941	Completed	Bladder Cancer, Urothelial Carcinoma	Diagnostic test: RT-qPCR	Zhongnan Hospital
	NCT04288141	Recruiting	HER2-positive Breast Cancer	Other: acquisition of blood samples and tumour tissue samples (biopsies)	King’s College London
	NCT03895216	Completed	Bone metastases		Istituto Ortopedico Rizzoli
	NCT05888558	Enrolling by invitation	Myasthenia Gravis	Device: body fluid diagnosis	First Affiliated Hospital of Jinan University
	NCT04939324	Active not recruiting	Lung Cancer, Exosomes, Non Small Cell Lung Cancer	Biological: blood samples at 2 sites: peripheral vein and tumor-draining vein	University Hospital, Limoges
	NCT05270174	Not yet recruiting	Explore Whether lncRNA-ElNAT1 in Urine Exosomes Can be Used as a New Target for Preoperative Diagnosis of Lymph Node Metastasis	Other: no intervention	Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
	NCT03608631	Active not recruiting	KRAS NP 004976.2:p.G12D, Metastatic Pancreatic Adenocarcinoma, Pancreatic Ductal Adenocarcinoma, Stage IV Pancreatic Cancer AJCC v8	Drug: mesenchymal stromal cells-derived exosomes with kras g12d siRNA	M.D. Anderson Cancer Center
Diabetes	NCT03264976	Unknown	Diabetic Retinopathy	Diagnostic test: hematological examination, ophthalmic examination	Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
	NCT02138331	Unknown	Diabetes Mellitus Type 1	Biological: MSC exosomes.	General Committee of Teaching Hospitals and Institutes, Egypt
	NCT05259449	Recruiting	Diabetes Mellitus, Type 2	Behavioral: nutritional education program, other: the high-intensity interval training (HIIT), other: the moderate-intensity continuous training (MICT)	University of Cadiz
	NCT06188013	Not yet recruiting	Diabetic retinopathy		Xuanwu Hospital, Beijing
	NCT05243368	Recruiting	Foot, Diabetic	Dietary supplement: personalized nutritional intervention	Maimónides Biomedical Research Institute of Córdoba
	NCT06198543	Not yet recruiting	Diabetic retinopathy		Xuanwu Hospital, Beijing
	NCT05989867	Recruiting	Chronic Pancreatitis, Pancreatogenic Type 3C Diabetes Mellitus, Diabetes Mellitus, Oral Glucose Tolerance Test	Diagnostic test: blood test, device: continuous glucose monitor	Changhai Hospital
	NCT06123871	Active not recruiting	Diabetic Nephropathy	Other: grouping based on previous laboratory results, no intervention.	Yipeng Liu
	NCT06097351	Active not recruiting	Diabetic Nephropathy	Other: grouping based on previous laboratory results, no intervention.	Yipeng Liu

Note: Data was retrieved from clinicaltrials.gov.