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. 2024 Mar 27;14(4):405. doi: 10.3390/biom14040405

Figure 1.

Figure 1

Increase in Schwann cell markers following DPSC-SC differentiation in three healthy donors. (A) Gene expression levels of P75NTR, S100B, MPZ, and LAMA2 increased in all three donors. (B) Representative ICC images of P75NTR, S100B, MPZ, and laminin 1 + 2 before (control) and after DPSC-SC differentiation. (C) Quantifications of P75NTR, S100B, laminin 1 + 2, and MPZ ICC compared to undifferentiated controls. Hoechst staining was used to visualize nuclei. Data are represented as mean ± SEM. (A): n = three experiments with three technical replicates for each donor. (C): n = one experiment with three technical replicates for each donor. (A,C): Unpaired t-tests or Mann–Whitney test. Samples were compared towards undifferentiated DPSCs of the same donor. * p < 0.05, ** p < 0.001, and *** p < 0.0001. P75NTR: P75 neurotrophic receptor, S100B: S100 calcium-binding protein B, LAMA2: laminin alpha-2, and MPZ: myelin protein zero.