Table 3.

Acute liver function test in male rats.

Acute HE (Liver Function Test, Male)	6 Weeks Aged Rats	5 Months Aged Rats	12 Months Aged Rats	24 Months Aged Rats
Control	ALT—49.2 ± 11.4 AST—97.9 ± 14.6	ALT—56.84 ± 9.68 AST—126.9 ± 18.6	ALT—62.4 ± 10.9 AST—131.7 ± 21.6	ALT—61.7 ± 16.4 AST—129.6 ± 19.2
TAA alone	ALT—816.9 ± 108.4 * AST—1987 ± 216.3 *	ALT—978.1 ± 116.8 * AST—2493 ± 316.9 *	ALT—959.3 ± 134.8 * AST—2652.7 ± 249.6 *	ALT—1162.9 ± 201.6 * AST—3108.9 ± 319.2 *
EtOH	ALT—69.3 ± 12.9 AST—141.3 ± 22.7	ALT—71.62 ± 14.9 AST—154.0 ± 21.6	ALT—81.9 ± 18.6 AST—168.7 ± 28.7	ALT—79.8 ± 20.3 AST—189.5 ± 28.6
TAA + EtOH	ALT—1219.6 ± 172.1 † AST—2801.6 ± 118.2 †	ALT—1311.7 ± 172.1 † AST—2819.6 ± 203.8 †	ALT—1272.8 ± 161.6 † AST—2918.3 ± 201.8 †	ALT—1619.4 ± 301.8 † AST—3672.1 ± 216.8 †≠

Mean values ± SD. Control n = 5; TAA n = 7; EtOH n = 5; TAA + EtOH n = 7. * p < 0.05 vs. control; † p < 0.05 vs. TAA; ≠ p < 0.05 vs. 6 weeks, 5 and 12 months. Hepatic encephalopathy (HE); alcohol (EtOH); thioacetamide (TAA), alanine aminotransferase (ALT); aspartate aminotransferase (AST).