Table 4.

Acute liver function test in female rats.

Acute HE (Liver Function Test, Female)	6 Weeks Aged Rats	5 Months Aged Rats	12 Months Aged Rats	24 Months Aged Rats
Control	ALT—52.4 ± 10.6 AST—112.8 ± 20.6	ALT—46.3 ± 9.4 AST—83.7 ± 16.2	ALT—61.7 ± 11.8 AST—124.2 ± 21.3	ALT—61.9 ± 19.4 AST—122.8 ± 31.6
TAA alone	ALT—906.3 ± 82.1 * AST—2110.6 ± 186.2 *	ALT—800.9 ± 107.3 * AST—1914.6 ± 184.6 *	ALT—946.2 ± 119.1 * AST—2496.3 ± 206.8 *	ALT—1174.9 ± 126.8 * AST—2392.6 ± 201.8 *
EtOH	ALT—69.2 ± 14.8 AST—131.9 ± 18.6	ALT—56.9 ± 9.2 AST—124.2 ± 31.9	ALT—72.6 ± 12.8 AST—146.3 ± 21.8	ALT—76.4 ± 18.1 AST—157.5 ± 22.9
TAA + EtOH	ALT—1519.8 ± 154.2 †≠ AST—3514.7 ± 202.4 †≠	ALT—1138.4 ± 105.1 †≠ AST—2591.3 ± 200.3 †≠	ALT—1201.7 ± 94.2 †≠ AST—2617.4 ± 192.2 †≠	ALT—1612.4 ± 141.8 †≠ AST—3491.5 ± 246.8 †≠

Mean values ± SD. Control n = 5; TAA n = 7; EtOH n = 5; TAA + EtOH n = 7. * p < 0.05 vs. control; † p < 0.05 vs. TAA; ≠ p < 0.05 vs. 5 and 12 months. Hepatic encephalopathy (HE); alcohol (EtOH); thioacetamide (TAA); alanine aminotransferase (ALT); aspartate aminotransferase (AST).