Table 2.

miRNAs Involved in Inflammation-Mediated Processes in Atrial Fibrillation.

miRNA	Target Genes/Pathways	Role in Inflammation
miR-146a	TLR4, IRAK1, TRAF6 NF-κB pathway	Negative regulator of innate inflammatory responses NET formation
miR-21	STAT3 pathway	Promotes inflammation-associated fibrosis
miR-355, miR-26b	GATA4	Alters fibroblast expression (cellular senescence) Affects atrial conduction through calcium homeostasis
miR-150	TGF-β EGRR2, P2X7R	Modulates inflammatory response system by targeting pro-inflammatory ATP receptor and multiple regulatory genes
miR-222	Associated with DVHD P27 ICAM-1	Role in inflammation-mediated vascular remodeling Downregulation of IRF-2