Figure 1.

NTCU treatment causes weight loss and decreased survival, independent of XPC expression. (A) Schematic representation of N-nitroso-tris-chloroethylurea (NTCU) treatment. (B) Weights (mean +/− SEM) by week, treatment (NTCU or acetone control), and genotype (XPC WT, XPC KO) in all male and (C) female mice. * p < 0.05, ** p < 0.01, *** p < 0.001 using Student t-tests by treatment. (D) Kaplan–Meier survival analysis by XPC genotype and (E) XPC genotype and sex, showing a decrease in survival with NTCU treatment but not other variables. * p < 0.05 using Gehan–Breslow test.