Figure 2.

XPC protects against NTCU-induced lung squamous cell carcinoma (LUSC). (A) Characteristic hematoxylin and eosin (H&E) stained bronchial epithelium showing histologic progression characteristic of that seen in humans from normal bronchial epithelium to metaplasia to dysplasia to LUSC. 40x objective (bar 50 µm), images cropped. Percent mice with (B) LUSC, (C) high-grade dysplasia, (D) metaplasia, and low-grade dysplasia by XPC expression. (E) Percent LUSC lung surface area by XPC expression per mouse (all mice lungs) and in only those mice who developed LUSC (tumors only). * p < 0.05 using Chi-Squared or Student t-test. N.S. = not significant.