Table 1.
Outcomes based on mouse genotype.
| Genotype | Treatment | Deaths/Sac Prior to 19.5 Weeks (Total Mice) | Mice with LUSC/Total * | Mice with LUSC or High-Grade Dysplasia/Total * | Other Findings |
|---|---|---|---|---|---|
| XPC +/+ | Acetone (control) | 0 (13) | 0/13 | 0/13 | |
| XPC +/+ | NTCU | 11 (37) Death: 3 Sac: 8 Δ |
5/26 M: 3/17 F: 2/9 |
8/26 M: 5/17 F: 4/9 |
Granuloma (1), early lymphoma (2) |
| XPC +/− | Acetone (control) | 0 (8) | 0/8 | 0/8 | |
| XPC +/− | NTCU | 5 (17) Death: 5 |
4/12 M: 2/4 F: 2/8 |
5/12 M: 2/4 F: 3/8 |
Early lymphoma (2) |
| XPC −/− | Acetone (control) | 0 (11) | 0/11 | 0/11 | |
| XPC −/− | NTCU | 12 (40) Death: 5 Sac: 7 Δ |
13/28 M: 6/12 F: 7/16 |
16/28 M: 7/12 F: 9/16 |
Early lymphoma (1), Granulomas (3) |
* At time of necropsy, excludes mice that died/sac < 19.5 weeks. Δ Sac= all sacrificed for severe/persistent cachexia other than two mice (XPC +/+, NTCU) that were sacrificed due to severe wounds/sores. LUSC = lung squamous cell carcinoma.