Table 2.

Treatment of glioblastoma cells with CK2 inhibitors.

Drug Name	Context	Impact
CX-4945 treatment alone and with TMZ	Mouse xenograft (GL261) and in vitro methods	Apoptosis induction, inhibition of cell migration, adhesion, and colony formation, inhibition of STAT3, NF-kB p56, and Akt; CX-4945 in combination TMZ had more robust impact [101]
CX-4945 treatment w/combined inhibitors: gefitinib and TMZ	In vivo mouse xenografts (GL261, SF767, U373, LN229) and in vitro methods	Inhibition of cell proliferation; CX-4945 sensitized TMZ-resistant cell lines (SF767) [101,103]
CX-4945 treatment w/combined inhibitor gefitinib	In vivo mouse xenograft (Xenograft X1046) and in vitro methods (X1016, X1046, X1066, U251-MG, U87MG)	Inhibition of tumor growth, cell proliferation, migration, adhesion; decreased activation of STAT3, NF-kB p56, and Akt; reduced stemness [104,105]