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Mechanisms of interplay between ATP and nucleic acids to modulate LLPS. Speculative models to illustrate how ATP and nucleic acids interplay to modulate LLPS: (a) FUS NTD; (b) FUS CTD; (c) TDP-43 PLD and its mutants including the ones with residues 312–342 deleted and with all five Arg mutated to Lys; (d) SARS-CoV-2 N (1–249).
