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ATP shapes the genome–proteome interface. (a) Major interactions between nucleic acids and proteins composed of intrinsically disordered regions (IDRs) and folded domains including the nucleic-acid-binding domain. (b) Major effects that ATP exerts on proteins composed of intrinsically disordered regions (IDRs) and well-folded domains including the nucleic-acid-binding domain. (c) ATP sits in between the genome and proteome in modern cells to regulate various biological functions.
