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. 2024 Apr 9;13(8):653. doi: 10.3390/cells13080653

Figure 7.

Figure 7

SAH depletes CGRP-IR nerve terminals in the TNC. (a) Representative photomicrographs showing CGRP-immunolabeling in the dorsal region of the TNC from a SHAM (top) and a SAH (bottom) animal. Scale bar: 500 μm. Inset: Magnified section of the dorsal lamina with CGRP-IR nerve fibers (red). Scale bar: 100 μm. (b) Density of CGRP-IR fibers was significantly reduced by SAH. Data were analyzed by the Mann–Whitney Rank Sum Test and the values are expressed as medians with range (IQR 25–75%). n = 6. *: p < 0.05. (c) The thickness of the CGRP-IR dorsal lamina in TNC was significantly narrowed in the SAH compared to the SHAM groups. Data are expressed as mean ± SEM and were analyzed by t-test. n = 6, *: p < 0.05. TNC: trigeminal nucleus caudalis, FG: fluorogold tracer, CGRP-IR: CGRP-immunoreactive nerve fibers.