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. 2024 Apr 13;10(4):262. doi: 10.3390/gels10040262

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Scheme of the hydrogel-based delivery system described by Hu et al. [146]. (A) Synthesis of OHA/HA-ADH-gels, highlighting their chemical versatility and ability to encapsulate SeNPs. (B) Osteoarthritis is characterized by selenium deficiency, oxidative stress, cartilage damage, and increased inflammatory cytokines. (C) The gels serve as an intra-articular platform for sustained SeNPs delivery to the inflamed joint. (D) They mitigate cartilage degeneration by restoring redox balance and inhibiting apoptosis via GPX1 activation. Copyright © 2023, Elsevier Ltd.