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Manhattan plot of APOE expression quantitative trait loci (eQTL). APOE mRNA levels from 405 dorsolateral prefrontal cortices were made available by ROSMAP using custom microarrays manufactured by Agilent Technologies. Trans-eQTL analysis revealed a genome-wide significant locus in TMEM106B gene region (p = 4.4 ×10−13). Top SNPs are indicated on the graph. Suggestive (blue) and genome-wide significant (red) thresholds were set to a -log10 p value of 5 and 7.3, respectively.
