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Manhattan plot illustrating the expression quantitative trait loci (eQTL) of TMEM106B. Custom microarrays manufactured by Agilent Technologies were used to measure TMEM106B mRNA levels from 405 dorsolateral prefrontal cortices from the ROSMAP cohort. A genome-wide significant locus in LINC01889 gene region was found by the trans-eQTL analysis (p = 1.3 × 10−8). Suggestive (blue) and genome-wide significant (red) thresholds were set to a -log10 p value of 5 and 7.3, respectively.
