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. 2024 Mar 26;15(4):416. doi: 10.3390/genes15040416

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Influence of TMEM106B coding variant T185S in the dorsolateral prefrontal cortex from ROSMAP individuals. (a) TMEM106B protein levels were significantly reduced in the presence of 185S amino acid (p < 0.001) in both unaffected (blue) and affected (red) individuals. (b) In both APOE4 negative (blue) and APOE4 positive (red) individuals, APOE mRNA levels were significantly lower in the Ser/Ser group (p < 0.001). Mean ± SEM are represented by shaded area of corresponding colors for each group.